Pharmaceuticals

Microscopy is key in the research, formulation and manufacturing stages of pharmaceutical product development. Both optical and scanning electron microscopy (SEM) are often used to optimize particle size, morphology and roughness of pharmaceutical materials. Understanding size distribution and morphology of pharmaceutical particles either containing active pharmaceutical ingredients (API) or excipients is critical for optimizing both the compounding process and product solubility.

  • Phenom SEMs can also be paired with energy-dispersive X-ray spectroscopy (EDS) to analyze chemical composition of pharmaceutical products or foreign particulate with sub-micron lateral resolution.
  • Pharmaceutical companies often utilize 3D optical profilometry to quantitatively determine the surface finish of tablets. Roughness is important to control when developing consistent tablet swallowability.

Particle Characterization
Particle Characterization

Particle size distribution, morphology and chemical composition

Quality Assurance
Quality Assurance

SEM imaging and EDS analysis applied to pharmaceutical QA/QC

Foreign Particle Analysis
Foreign Particle Analysis

Use SEM/EDS to determine the composition of foreign particles extracted from injectable drug compounds.

Deformulation
Deformulation

Deformulation, also referred to as reverse engineering, for the pharmaceutical industry

Surfaces and Coatings
Surfaces and Coatings

Characterize pharmaceutical surfaces and coatings with 3D profilometry, AFM, SEM and elemental analysis

Pharmaceuticals Testimonials
Pharmaceuticals Testimonials

Case studies using the Phenom SEM for pharmaceutical and medical research